oxidation of meloxicam by streptomyces griseus

Oxidation of Meloxicam by Streptomyces griseus

The aim of the present investigation was to biotransform the anti-inflammatory compound meloxicam by enzymes present in whole cells of five actinomycete cultures to produce novel bioactive derivatives. Among the actinomycetes screened, Streptomyces griseus NCIM 2622 was found to possess the enzyme system(s) that oxidize meloxicam into two metabolites whereas that present in S. griseus NCIM 2623...

Biogenesis of chromomycin A3 by Streptomyces griseus.

The biosynthesis of chromomycin A3 was investigated using 13C-labeled acetates, methionine and glucose, and 13C,18O-labeled acetate. 13C NMR spectral analysis demonstrated that: Aglycone assembly occurs by combining at least two polyketide chains; three of nine oxygen atoms of the aglycone originate from acetate precursor oxygen atoms; carbon methylations on the aromatic ring at C-7, on the chr...

Isolation and characterization of a phage active against streptomyces griseus

Genetic recombination in Streptomyces griseus.

Low-frequency (10(-6)) genetic recombination was observed in a cephamycin-producing strain of Streptomyces griseus. The recombinants were predominantly heteroclones. Heteroclone analysis was performed involving four heteroclones of one cross. In 100 mutants correlation was found between the type of auxotrophy and the level of antibiotic activity. A cross of this strain with a streptomycin-produ...

Variants of Streptomyces griseus induced by ultraviolet radiations.

The search for microorganisms giving higher yields of desired fermentation products has profited from the use of mutagenic agents. This approach has proved especially valuable in the isolation of superior strains of antibiotic producing cultures. However, large numbers of isolates must be tested because many are inferior to or no better than the parent organism. There is need for a method which...

Utilization of carbohydrates by strains of Streptomyces griseus.

The utilization of various carbohydrates by species of streptomyces has been suggested by Pridham and Gottlieb (1948), Kurosawa (1951), and Benedict et al. (1955) as an aid in differentiation of species. While the latter investigators have reported that streptomycin-producing strains of Streptomyces griseus will grow on synthetic agar media containing as sole carbon source mannitol, xylose, fru...